Nemesis Lockdown is the first stand alone expansion to Nemesis. During the game, players will be taken to a totally new location - a secret base on Mars, represented by a multi level board. Lockdown will retain the highly cinematic, semi-co-op experience of the original game, while introducing a lot of new, fresh mechanics.

During the tense gameplay, you and your fellow players will gather items, explore different rooms and use your actions, craft, run, and fight other species. At the same time, every player will try to complete their secret objective, that will grant them victory... Sometimes at the expense of others.

Some of the new mechanics are:
- Multi-level base with stairs and elevators
- Advanced computer actions
- CSS hatch system
- Power and light on different levels
- Contingency procedure
- New characters and alien race